diff --git a/meta/conf/layer.conf b/meta/conf/layer.conf
index 54fa04e213..ba25ca3029 100644
--- a/meta/conf/layer.conf
+++ b/meta/conf/layer.conf
@@ -116,6 +116,13 @@ SSTATE_EXCLUDEDEPS_SYSROOT += "\
     .*->perlcross-native \
     libarchive-native->e2fsprogs-native \
 "
+# rpm-sequoia-native does not need most of its build dependencies to run,
+# so omit them. The necessary ones are openssl-native, and implicitly,
+# libgcc-native and the C runtime. Omitting these build dependencies can save
+# significant disk space and speeds up packaging into signed rpms a little.
+SSTATE_EXCLUDEDEPS_SYSROOT += "\
+    rpm-sequoia-native->(pkgconfig-native|cargo-native|python3-native|rust-native) \
+"
 # Nothing needs to depend on libc-initial
 # base-passwd/shadow-sysroot don't need their dependencies
 SSTATE_EXCLUDEDEPS_SYSROOT += "\